Ahh, we get to one of my more favorite characters. Apocalypse, being a boss character has no defense what-so-ever and is an easy target to hit also. The draw back is his attacks hurt if you don't block(His Drill and Eye Beam especially). Something interesting to note is that Apocalypse can not turn around, so if you can get around him you are safe from most of his attacks.
"You are not fit to survive!"