Are ISA Motherboards still available? Very much so. They are still in demand and used in applications that require a computer to control other machinery like CNC routers, manufacturing, POS, and numerous other applications. Not only are ISA Motherboards available, they are available in several form factors and in several configurations. Go to http://www.interloper.com/mbsearch.php and our configurator will help you drill down to the type of ISA motherboard you need.